重症患者机体受到感染之后，炎性反应呈级联式放大，而人体为对抗炎症反应而形成的代偿性反应综合征，一旦患者发生全身性炎性反应与代偿性抗炎反应紊乱，可以导致其体内的环境稳态被破坏，出现组织损伤，最终出现多种器官的功能衰竭[1]。尊龙凯时公司针对不同类型危重症患者提供吸附解决方案，尊龙凯时HA一次性血液灌流器，原研经典，广谱吸附，有效清除以炎症介质为代表的中大分子，可用于脓毒症[2-3]、重症急性胰腺炎（SAP）[4-5]、急性呼吸窘迫综合征（ARDS）[6-7]等炎症因子相关性疾病及心外科手术患者[8]；CA330细胞因子吸附柱，中国首个获批医疗器械注册证的细胞因子吸附类产品，专用于脓毒症患者炎症早期或细胞因子风暴期。血液吸附危重症领域治疗模式多样，临床上可以根据实际情况单独灌流使用，也可与其他血液净化模式联合使用，如HP+HD/HDF/CVVH、PFAD/CPFA[17]、(PFAD-HD)/ CPFA-CRRT[17]、HP+CPB、HP+ECMO，进行全血或者血浆灌流治疗。 参考文献： 血液灌流可用于人体内内源性和外源性代谢产物、毒物及余量药物的清除,已被写入多项急性中毒专家共识，针对各类急性中毒患者，HA一次性血液灌流器，原研经典，足程净化，可用于有机农药中毒[1-5]、药物中毒[6-7]、除草剂中毒[9-13]、毒蕈中毒[14-16]、蜂蛰伤[17]等急性中毒的抢救治疗。临床上可以利用多类血液净化动力装置单独灌流使用，也可与其他血液净化器联合使用，进行全血或者血浆灌流治疗。可在灌流机(JF-800A),Future F20血液净化设备、透析机、CRRT机（如尊龙凯时DX-10）等多种血液净化设备上完成治疗。 参考文献：
[1]Sasaki S，Hasegawa T，Kawarazaki H，et al． Development and validation of a clinical prediction rule for bacteremia among maintenance hemodialysis patients in outpatient setting［J］．PLoS One，2017，12( 1) : e0169975．
[2]Zhao Huang, Si-rong Wang, Zi-li Yang, and Ji-yun Liu. Effect on Extrapulmonary Sepsis-Induced Acute Lung Injury by Hemoperfusion With Neutral Microporous Resin Column[J]. Therapeutic Apheresis and Dialysis, 2012:1-8.
[3]Huang Z, Wang SR, Su W, Liu JY. Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column. Ther Apher Dial.2010 Dec;14(6):596-602.
[4]Sun, Shiren, et al. "High-volume hemofiltration plus hemoperfusion for hyperlipidemic severe acute pancreatitis: a controlled pilot study." Annals of Saudi medicine 35.5 (2015): 352-358.
[5]Tang Y, Zhang L, Fu P, et al. Hemoperfusion plus continuous veno-venous hemofiltration in a pregnant woman with severe acute pancreatitis: a case report.[J]. International Urology & Nephrology,2012, 44(3):987-990.
[6]Xu, Xuefeng, et al. "Effect of HA330resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model." Annals of intensive care 7.1 (2017): 84.
[7]Li, Cong, Nana Xu, and Tie Xu. "Therapeutic Effects of Hemoperfusion Combined with High Volume Hemofiltration on Acute Respiratory Distress Syndrome Short Title: Treatment of ARDS." Revista Argentina de Clinica Psicológica 29.3(2020):311.
[8]Zijian He, etal. The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass. Blood Purif.2021 Jun 9;1-7.
[9]ZHANG Lin,et al.Clinical study of mechanical ventilation combined with hemoperfusion and purification in the treatment of pneumothorax complicated by respiratory failure caused by traffic accident.Chin J Emerg Resusc Disaster Med.2021.
[10]Yuan,Hai,et al."Efficacy of two combinations of blood purification techniques for the treatment of multiple organ failure induced by wasp stings."Blood Purification 42.1 (2016):49-55.
[11]Zijian He,et al.The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass.Blood Purif.2021 Jun 9;1-7.
[12]Xu,Xuefeng,et al."Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model."Annals of intensive care 7.1 (2017):84.
[13]Li,Cong,Nana Xu,and Tie Xu."Therapeutic Effects of Hemoperfusion Combined with High Volume Hemofiltration on Acute Respiratory Distress Syndrome Short Title:Treatment ofARDS."Revista Argentina de Clinica Psicológica 29.3 (2020):311.
[14]Wang,Y.T.,et al."Effects of hemodialysis and hemoperfusion on inflammatory factors and nuclear transcription factors in peripheral blood cell of multiple organ dysfunction syndrome."Eur Rev Med Pharmacol Sci 20.4 (2016):745-50.
[15]Huang Bin,et al.Clinical study of continuous veno-venous hemofiltration combined with hemoperfusion in the treatment of severe burn sepsis.Journal of Clinicalemergency(China).2019:1009-5918.
[16]Prof.Claudio Ronco.CENTRO SPECIALIZZATO REGIONALE.PER LE TERAPIE DIALITICHE NELL'INSUFFICIENZA RENALE ACUTA E CRONICA E PER LE TECNOLOGIE EXTRACORPOREE di SUPPORTO MULTI-ORGANICO.2020.
[17]Ronco, C., & Bellomo, R. (2022). Hemoperfusion: technical aspects and state of the art. Critical care (London, England), 26(1), 135. http://doi.org/10.1186/s13054-022-04009-w.临床应用
急性中毒吸附解决方案
[1]杨立山,卢中秋,田英平,等.急性有机磷农药中毒诊治临床专家共识(2016)[J].中国急救医学,2016.
[2]张明浩,张伟,简伟明,等.血液灌流治疗急性重度有机磷农药中毒安全性和有效性的Meta分析[J].医学综述,2020,26(14):8. [11]LI,Z.,WANG,G.,ZHEN,G.,etal.(2017).Applicationofhemoperfusioninsevereacuteorganophosphorus pesticidepoisoning.TURKISHJOURNALOFMEDICALSCIENCES,47,1277-1281.doi:10.3906/sag-1611-40.
[3]杜宇,牟奕,赵立强.血液灌流治疗次数对重度急性有机磷农药中毒疗效和预后的影响[J].中国中西医结合急救杂志,2013,20(5):289-292.
[4]赵宏宇,韩新飞,赵敏,等.血液灌流治疗急性重度有机磷农药中毒的起始时间与疗效的相关性研究[J].中国全科医学,2011.14(14):1603-1604.1607.
[5]李勇,吴征臻李龙急诊床旁血液灌流治疗老年镇静催眠类药物中毒的疗效[J].临床急诊杂志,2021,22(1):60-64.
[6]吴刚,陈阵刘易珏早期床旁血液灌流治疗急性抗精神病药物中毒的临床观察[J].现代医药卫生,2015,31(7):1042-1044.
[7]郭利涛,刘昱,张蕾,王雪,等.血液灌流救治百草枯中毒方法探讨[J].重庆医学,2013,42(5):552-553.
[8]Chen AB, Li F, Di EM, Zhang X, Zhao QY, Wen J. Influence of strengthened hemoperfusion combined with continuous venovenous hemofiltration on prognosis of patients with acute paraquat poisoning: SHP + CVVH improve prognosis of acute PQ patients. BMC Pharmacol Toxicol. 2020 Jul 6;21(1):49.
[9]孙亮,燕彭波,李国峰,等.双罐串联血浆灌流对血浆百草枯清除效果的研究[J].中国血液净化,2013,12(3):149-151.
[10]中国医师协会急诊医师分会.急性百草枯中毒诊治专家共识(2013)[J].中国急救医学,2013,33(6):6.
[11]百草枯中毒诊断与治疗'泰山共识'专家组,菅向东.百草枯中毒诊断与治疗"泰山共识"(2014)[J].中国工业医学杂志,2014(2):117-119.
[12]赵航,赵敏,急性毒蕈中毒的临床分析[J].中国医科大学学报,2020,49(5):433-436.
[13]林洁羽,董伟,血液灌流联合血液滤过与单纯血液滤过治疗重症毒蕈中毒效果比较[J].广州医药,2020,51(2):27-30.
[14]丁文飞,吴蔚桦,文莉,等,不同血液净化方式治疗毒蕈中毒的临床观察[J].广州医药,2020,51(2):27-30.
[15]中国医师协会儿科医师分会血液净化专业委员会,儿童血液灌流临床应用专家共识[J].中国小儿急救医学,2018.25(8):8.
[16]中国毒理学会中毒与救治专业委员会中华医学会湖北省急诊医学分会,湖北省中毒与职业病联盟.胡蜂螫伤规范化诊治中国专家共识[J].中华危重病急救医学,2018,30(9):5.
[17]程辉,文申英,刘超.血液灌流联合连续性肾脏替代治疗在蜂蜇伤致横纹肌溶解合并急性肾损伤中的应用价值[J].临床和实验医学杂志,2020,19(16):4.
